Catalog Number - 85318-PG1

The 85318‑PG1 Cogent RP C18 ABX™ Guard Column Cartridges are engineered for high‑efficiency protection of narrow‑bore LC‑MS columns, providing reliable removal of particulates, strongly retained compounds, and matrix contaminants.

Packed with 3 µm RP C18 ABX™ stationary phase, these cartridges feature bulky end‑capping on high‑purity silica, ensuring stable chromatographic performance across extreme pH conditions (2–12).

Designed for 2.1 mm ID Columns (LC‑MS / Low Flow)

• Optimized for:

  • 2.1 mm ID LC‑MS columns

  • low‑flow analytical HPLC systems

Typical Flow Rate Range

• ~0.2–0.3 mL/min

✅ Requires precise low‑flow pump capability and compatible detector volumes

✅ Maintains chromatographic integrity at low flow rates

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained acidic and basic analytes

  • Matrix fouling and buildup

• Extend column lifetime

• Maintain retention reproducibility and peak shape

• Reduce downtime and replacement costs

3 µm Guard Media – High‑Efficiency LC‑MS Protection

• Matches high‑efficiency analytical column packings

• Preserves resolution and chromatographic performance

• Ideal for sensitive LC‑MS workflows

✅ Provides maximum protection with minimal impact on efficiency

Why Choose RP C18 ABX™ Guard Cartridges (3 µm)

Matched Extreme pH Chemistry

• Same ABX™ stationary phase as analytical column

• Maintains selectivity and retention behavior

• Supports full pH 2–12 operation

Enhanced LC‑MS Protection

• Reduces contaminants entering:

  • Analytical column

  • LC‑MS system and detector

Workflow Efficiency

• Minimizes column replacement frequency

• Improves instrument uptime and reproducibility

Cogent RP C18 ABX™ Advantages

Extreme pH Stability

• Reliable operation across pH 2–12

• Ideal for acidic and basic compound separations

Bulky End‑Capping

• Reduces secondary interactions

• Improves peak symmetry and consistency

Durable Construction

• Stainless steel cartridge body

• Stainless steel frits

• PEEK frit caps

✅ Designed for low‑flow, high‑sensitivity environments

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed specifically for 2.1 mm LC‑MS and low‑flow HPLC systems

• Ideal for extreme pH workflows (pH 2–12)

• Replace regularly to maintain optimal system performance

Helpful Resource & Link

• 👉 View guard column holders and compatibility options for these cartridges